Get A Systems Biology Approach to Blood PDF

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

ISBN-10: 1493920944

ISBN-13: 9781493920945

ISBN-10: 1493920952

ISBN-13: 9781493920952

The blood approach is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood involves circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments consequence from a highly-ordered method, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells supply upward thrust to a number of lineages of hugely really expert cells. Highly-productive and consistently regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A platforms Biology method of Blood is split into 3 major sections: simple parts, physiological strategies, and medical functions. utilizing blood as a window, you will research health and wellbeing and illness via this certain software field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and some of the blood mobilephone varieties. Many blood ailments, infrequent and customary can and feature been exploited utilizing structures biology techniques with profitable effects and hence excellent versions for platforms medication. extra importantly, hematopoiesis deals the best studied platforms with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are on a daily basis prompted by way of the main mature and understood regulatory networks.

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J Biol Chem. 2004;279(23):24218–25. 36. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, et al. Tie2/angiopoietin- 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004;118(2): 149–61. 37. Thoren LA, Liuba K, Bryder D, Nygren JM, Jensen CT, Qian H, et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 2008;180(4):2045–53. 38. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

J Bone Miner Res. 1997;12(12):1959–70. 2 Quantification and Modeling of Stem Cell– Niche Interaction 35 51. Charbord P. Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther. 2010;21(9):1045–56. 52. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131(2):324–36. 53. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al.

In particular, to study and analyze stem cell–niche interactions, corresponding models have to: • Be based on populations of individual cells to follow clonal development, to conform with the uncertainty principle and to enable considerations of population fluctuations. • Consider growth environments and their interactions with cells. • Be dynamic in time and space. , homing). • Be comprehensive in the sense of being applicable to the normal, unperturbed in vivo homeostasis as well as to any in vivo or in vitro assay procedure.

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A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard


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