By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard
The blood approach is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood involves circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments consequence from a highly-ordered method, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells supply upward thrust to a number of lineages of hugely really expert cells. Highly-productive and consistently regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.
A platforms Biology method of Blood is split into 3 major sections: simple parts, physiological strategies, and medical functions. utilizing blood as a window, you will research health and wellbeing and illness via this certain software field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and some of the blood mobilephone varieties. Many blood ailments, infrequent and customary can and feature been exploited utilizing structures biology techniques with profitable effects and hence excellent versions for platforms medication. extra importantly, hematopoiesis deals the best studied platforms with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are on a daily basis prompted by way of the main mature and understood regulatory networks.
Read or Download A Systems Biology Approach to Blood PDF
Similar biology books
The entire sequencing of the human genome and plenty of new microarray and proteomic tools for studying international alterations in either gene expression and protein profiles have enormously elevated our skill to appreciate transmembrane signaling strategies in shut element. during this totally up to date and accelerated moment variation of Transmembrane Signaling Protocols, prime specialists reveal using such thoughts as single-cell imaging, bioluminescence resonance strength move, and worldwide proteomics within the learn of transmembrane signaling occasions.
Normal Editor: Peter Calow, division of Zoology, college of Sheffield, England the most objective of this sequence should be to demonstrate and to give an explanation for the best way organisms 'make a residing' in nature. on the middle of this - their func tional biology - is the way in which organisms gather after which utilize assets in metabolism, circulate, development, copy, and so forth.
'Provides accomplished aspect at the a variety of elements of specific molecules fascinated about the stages of harm and service and the mobile pursuits and methods. .. .This is a superb reference ebook for libraries serving biology and health and wellbeing technological know-how shoppers and for staff during this box of study.
- Bacterial Adhesion to Host Tissues: Mechanisms and Consequences
- Plant Molecular Biology 2
- Lung Biology in Health & Disease Volume 158 Ventilator Management Strategies for Critical Care
- Receptor Signal Transduction Protocols
- Organelle Proteomics
Extra resources for A Systems Biology Approach to Blood
J Biol Chem. 2004;279(23):24218–25. 36. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, et al. Tie2/angiopoietin- 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004;118(2): 149–61. 37. Thoren LA, Liuba K, Bryder D, Nygren JM, Jensen CT, Qian H, et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 2008;180(4):2045–53. 38. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.
J Bone Miner Res. 1997;12(12):1959–70. 2 Quantification and Modeling of Stem Cell– Niche Interaction 35 51. Charbord P. Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther. 2010;21(9):1045–56. 52. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131(2):324–36. 53. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al.
In particular, to study and analyze stem cell–niche interactions, corresponding models have to: • Be based on populations of individual cells to follow clonal development, to conform with the uncertainty principle and to enable considerations of population fluctuations. • Consider growth environments and their interactions with cells. • Be dynamic in time and space. , homing). • Be comprehensive in the sense of being applicable to the normal, unperturbed in vivo homeostasis as well as to any in vivo or in vitro assay procedure.
A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard