By Eric Kvaalen, Philip C. Wankat
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Extra resources for Alchohol Distillation Principles Equipment Relationships and Safety
An acute-duration study reported a 71% increase in absolute weight of the uterus in ovariectomized rats administered 110–146 mg 4,4N-methylenedianiline by gavage for 5–14 days (Tullner 1960). METHYLENEDIANILINE 2. HEALTH EFFECTS Histopathological examination of the uterus revealed an atypical folliculoid response in the endometrium. No further information was provided in this study. No gross or histopathogical alterations were observed in the ovaries, uterus, mammary glands, seminal vesicles, prostate, or testes of rats administered up to 141 mg 4,4N-methylenedianiline/kg/day in drinking water for 13 weeks or up to 19 mg/kg/day for 103 weeks (Lamb et al.
1987). The authors attributed this temporary loss in weight to the stress of being restrained during exposure since the trend over the entire experimental period was similar between exposed and control animals. No further information was located regarding body weight effects after inhalation exposure to 4,4N-methylenedianiline. 5. METHYLENEDIANILINE 2. 8 Cancer No studies were located regarding carcinogenic effects in humans or animals after inhalation exposure to 4,4N-methylenedianiline. 1 Death No cases of human deaths attributed to oral exposure to 4,4N-methylenedianiline were located in the literature reviewed.
The authors indicated that using acetone as solvent may have provided inaccurate results since 4,4N-methylenedianiline tends to form a Schiff base with acetone. The same group of investigators (Holland et al. 3 mg 4,4N-methylenedianiline/kg/day 3 times per week for 104 weeks. 9% in treated mice. LOAEL values for death for each species and duration category are recorded in Table 2-3. METHYLENEDIANILINE 2. 2 Systemic Effects No studies were located regarding respiratory effects in humans or musculoskeletal effects in humans or animals after dermal exposure to 4,4N-methylenedianiline.
Alchohol Distillation Principles Equipment Relationships and Safety by Eric Kvaalen, Philip C. Wankat