By Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)
Aminopeptidases in Biology and Disease offers a finished assessment of the rising function of aminopeptidases in quite a number organic methods and ailment occasions. strategies as assorted as angiogenesis, antigen presentation, neuropeptide and hormone processing, being pregnant and copy, protein turnover, reminiscence, irritation, tumour development, melanoma and metastasis, blood strain and high blood pressure all seriously contain a number of aminopeptidases. the person chapters were written by means of specialists within the box who've supplied targeted bills of the critical roles performed by way of quite a few aminopeptidases in biology and disease.
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Additional info for Aminopeptidases in Biology and Disease
Angiogenesis is a key factor in a number of vascular and vascular-related diseases (for review see Folkman 1997). Thus, the modulation of angiogenesis could be potentially beneficial in the treatment of these diseases. This is an especially promising modality in the treatment of cancer where angiogenesis is an essential factor in tumor growth and metastasis (Folkman 1997). The fumagillin class of anti-angiogenesis antibiotics ("angioinhibins" Ingber et al. , ovalicin, isolated from Pseudorotium ovalis (Sigg and Weber 1968) to the naturally occurring antibiotic fumagillin (Figure 3), are the most potent natural angiogenesis inhibitors discovered to date (Figure 3) (for Methionine Aminopeptidase 31 review see Kruger and Figg 2000).
There is recent evidence, however, that both forms of Metinit hydrolysis are common in higher eukaryotes; Metinit hydrolysis takes place in the cytosol, and f-Metinit hydrolysis takes place in chloroplasts and mitochondria (Giglione et al. 2000b). 2. 1 MetAP Isoforms Two major classes of MetAPs, designated type I and type 2 (MetAPI and MetAP2), were originally identified as cytosolic proteins (Arfin et al. 1995; Li and Chang 1995). The two classes are structurally similar but share little sequence homology (Lowther and Matthews 2000).
2000). Although p21WAFIICIPI is a MetAP substrate (Met-Ser-), the requirement of p53 for p21WAFIICIPI expression also rules out 38 VETRO, DUMMITT, AND CHANG Chapter 2 a direct stabilization of p2lwAFIICIPI by MetAP2 inhibition (Zhang et al. 2000) . 5. CONCLUSION Much work remains in understanding the functions of MetAPl and MetAP2, their substrate specificities, and their subcellular distributions in higher animal cells. Further studies in these areas should help in elucidating the mechanism of lethality that results from Metinit retention as well as the role of MetAP2 catalytic activity in angiogenesis.
Aminopeptidases in Biology and Disease by Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)